集锦-智能医药实验室

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Recent Representative Publications (View)

341. Sheng Zhao, Ziyi Lu, Ruisi Cai, Hui Wang, Shukun Gao, Changwei Yang, Ying Zhang, Bowen Luo, Wentao Zhang, Yinxian Yang, Shenqiang Wang, Tao Sheng, Shiqi Wang, Jiahuan You, Ruyi Zhou, Huimin Ji, Haoning Gong, Xiao Ye, Jicheng Yu*, Hong-Hu Zhu*, Yuqi Zhang*, Zhen Gu*.

A wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models, Science Translational Medicine, 2024, 16(775): eadp3611.

DOI: 10.1126/scitranslmed.adp361

340. Tingxizi Liang+, Yuxiang Dong+, Irina Cheng, Ping Wen, Fengqin Li, Feng Liu, Qing Wu, En Ren, Peifeng Liu*, Hongjun Li*, Zhen Gu*.

In Situ Formation of Biomolecular Condensates as Intracellular Drug Reservoirs for Augmenting Chemotherapy, Nature Biomedical Engineering, in press, 2024.

DOI: 10.1038/s41551-024-01254-y

339. Xinwei Wei+, Yanfang Wang+, Huihui Hu+, Yuejun Yao, Changming Chen, Guangzheng Xu, Kaihui Li, Yuyan Su, Kewang Nan*, Jinqiang Wang*, Zhen Gu*.

TBA, Nature Reviews Electrical Engineering, in press, 2024.

DOI: -

338. Kangfan Ji, Xiangqian Wei, Anna R. Kahkoska, Juan Zhang, Yang Zhang, Jianchang Xu, Xinwei Wei, Wei Liu, Yanfang Wang, Yuejun Yao, Xuehui Huang, Shaoqian Mei, Yun Liu, Shiqi Wang, Zhengjie Zhao, Ziyi Lu, Jiahuan You, Guangzheng Xu, Youqing Shen, John. B. Buse, Jinqiang Wang*, Zhen Gu*.

An Orally Administered Glucose-Responsive Polymeric Complex for High-Efficiency and Safe Delivery of Insulin in Mice and Pigs, Nature Nanotechnology, in press, 2024.

DOI: s41565-024-01764-5

337. Yanfang Wang, Jiaqi Shi, Minhang Xin, Anna Kahkoska, Jinqiang Wang*, Zhen Gu*.

Cell-drug Conjugates, Nature Biomedical Engineering, in press, 2024.

DOI: 10.1038/s41551-024-01230-6

336. Yun Liu+, Shiqi Wang+, Zejun Wang, Jicheng Yu, Jinqiang Wang, John B. Buse*, Zhen Gu*.

Recent Progress in Glucose-Responsive Insulin, Diabetes, db240175, 2024.

DOI: 10.2337/dbi23-0028

335. Zhaoting Li+, Yixin Wang+, Zhen Gu*, Quanyin Hu*.

Engineering Cells for Therapy and Diagnosis, Nature Reviews Bioengineering, in press, 2024.

DOI: 10.1038/s44222-024-00198-x

334. Jiaqi Shi+, Wei Wu+, Dong Chen+, Ziyan Liao, Tao Sheng, Yanfang Wang, Yuejun Yao , Qing Wu , Feng Liu, Ruyi Zhou, Chaojie Zhu, Xinyuan Shen, Zhengwei Mao, Yuan Ding, Weilin Wang, Gianpietro Dotti, Jie Sun, Xiao Liang, Weijia Fang, Peng Zhao*, Hongjun Li*, Zhen Gu*.

Lyophilized Lymph Nodes for Improved Delivery of Chimeric Antigen Receptor T Cells, Nature Materials, 121(11): e2314349121, 2024.

DOI: 10.1038/s41563-024-01825-z

333. Xue Tian, Mingxing Feng, Xinwei Wei, Cheng Cheng, Kaixin He, Tianyue Jiang*, Bingfang He*, Zhen Gu*.

In Situ Formed Depot of Elastin-like Polypeptide-hirudin Fusion Protein for Long-term Antithrombotic Therapy, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 121(11): e2314349121, 2024.

DOI: 10.1073/pnas.2314349121

332. Jing Bai+, Dingyao Liu+, Xinyu Tian+, Yan Wang, Binbin Cui, Yilin Yang, Shilei Dai, Wensheng Lin, Jixiang Zhu, Jinqiang Wang, Aimin Xu, Zhen Gu*, Shiming Zhang*.

Coin-sized, Fully Integrated, and Minimally Invasive Continuous Glucose Monitoring System Based on Organic Electrochemical Transistors, Science Advances, 10(16): eadl1856, 2024.

DOI: 10.1126/sciadv.adl1856

331. Feng Liu+, Minhang Xin+, Huiheng Feng, Wentao Zhang, Ziyan Liao, Tao Sheng, Ping Wen, Qing Wu, Tingxizi Liang, Jiaqi Shi, Ruyi Zhou, Kaixin He*, Zhen Gu*, Hongjun Li*.

Cryo-shocked Tumor Cells Deliver CRISPR-Cas9 for Lung Cancer Regression by Synthetic Lethality, Science Advances, 10(13): eadk8264, 2024.

DOI: 10.1126/sciadv.adk8264

330. Shiqi Wang, Changwei Yang, Wentao Zhang, Sheng Zhao, Jiahuan You, Ruisi Cai, Hao Wang, Yuhang Bao, Ying Zhang, Juan Zhang, Kangfan Ji, Yuqi Zhang, Xiao Ye*, Zhen Gu*, Jicheng Yu*.

Glucose-Responsive Microneedle Patch with High Insulin Loading Capacity for Prolonged Glycemic Control in Mice and Minipigs, ACS Nano, in press, 2024.

DOI: 10.1021/acsnano.4c05562

329. Ruyi Zhou, Hao Yu, Tao Sheng, Yingke Wu, Yingxin Chen, Jiahuan You, Yinxian Yang, Bowen Luo, Sheng Zhao, Yi Zheng, Hongjun Li, Yuqi Zhang*, Yugang Guo*, Zhen Gu*, Jicheng Yu*.

Grooved Microneedle Patch Augments Adoptive T Cell Therapy against Solid Tumors via Diverting Regulatory T Cells, Advanced Materials, 2401667, 2024.

DOI: 10.1002/adma.202401667

328. Bo Zhang+, Jialiang Lu+, Xu Lin+, Jinqiang Wang+, Qi Li, Tingting Jin, Qiuqiu Shi, Yang Lu, Jingyu Zhang, Jun Deng, Yinqiong Zhang, Yu Guo, Jian Gao, Haifeng Chen, Youyou Yan, Jiahe Wu, Jianqing Gao, Jinxin Che, Xiaowu Dong*, Zhen Gu*, Nengming Lin*.

Injectable and Sprayable Fluorescent Nanoprobe for Rapid Real-Time Detection of Human Colorectal Tumors, Advanced Materials, 2405275, 2024.

DOI: 10.1002/adma.202405275

327. Zhengjie Zhao, Yinxian Yang, Tao Sheng, Yuhang Bao, Ruixi Yu, Xinmin Yu, Shuangxu Jia, Qing Wu, Chaojie Zhu, Xinyuan Shen, Wentao Zhang, Ziyi Lu, Kangfan Ji, Xiaofeng Chen, Xinyun Jiang, Yuqi Zhang, Zhen Gu*, Jicheng Yu*.

Platelet-Drug Conjugates Engineered via One-step Fusion Approach for Metastatic and Postoperative Cancer Treatment, Angewandte Chemie International Edition, e202403541, 2024.

DOI: -10.1002/anie.202403541

326. Zhen Gu*.

Design and Application of Biotechnology Drug Delivery Systems, Progress in Pharmaceutical Sciences, 48(6): 401-402. 2024.

DOI: 10.20053/j.issn1001-5094.2024.06.001

325. Xiaorong Lin, Kaixin He, Zhen Gu, Xiaohui Zhao*.

Emerging Chemophysiological Diversity of Gut Microbiota Metabolites, Trends in Pharmacological Sciences, 45 (9), 824-838, 2024.

DOI: 10.1016/j.tips.2024.07.006

324. Shijie Li+, Sarun Juengpanich+, Win Topatana+, Tianao Xie, Lidan Hou, Yiyuan Zhu, Jiadong Chen, Yukai Shan, Yina Han, Ziyi Lu, Tianen Chen, Charlie Topatana, Bin Zhang, Jiasheng Cao, Jiahao Hu, Jiafei Yan, Yingxin Chen, Zhen Gu, Jicheng Yu*, Xiujun Cai*, Mingyu Chen*.

Adavosertib-Encapsulated Metal-Organic Frameworks for p53-Mutated Gallbladder Cancer Treatment via Synthetic Lethality, Science Bulletin, 69(9): 1286-1301, 2024.

DOI: 10.1016/j.scib.2024.02.039

323. Yajun Xu, Jianlin Lv, Fuyao Liu, Jinqiang Wang, Ya Liu, Chaoying Kong, Yanran Li, Na Shen*, Zhen Gu*, Zhaohui Tang*, Xuesi Chen.

Tumor Microenvironment Remodeling-mediated Sequential Drug Delivery Potentiates Treatment Efficacy, Advanced Materials, 2312493, 2024.

DOI: 10.1002/adma.202312493

322. Huipeng Zhang, Chaoyang Meng, Xuewen Yi, Jinpeng Han, Junxia Wang, Feng Liu, Qi Ling, Hongjun Li*, Zhen Gu*.

Fluorinated Lipid Nanoparticles for Enhancing mRNA Delivery Efficiency, ACS Nano, 18(11): 7825-7836, 2024.

DOI: 10.1021/acsnano.3c04507

321. Ziyan Liao+, Jie Jiang+, Wei Wu, Jiaqi Shi, Yanfang Wang, Yuejun Yao, Tao Sheng, Feng Liu, Wei Liu, Peng Zhao, Feifei Lv, Jie Sun*, Hongjun Li*, Zhen Gu*.

Lymph Node-biomimetic Scaffold Boosts CAR-T Therapy Against Solid Tumor, National Science Review, nwae018, 2024.

DOI: 10.1093/nsr/nwae018

320. Huiheng Feng, Irina Cheng, Fuyao Liu*, Zhen Gu*, Hongjun Li*.

Autologous Material-inspired Drug Delivery Systems, Science China Materials, 1-20, 2024.

DOI: 10.1007/s40843-024-2935-y

319. Fang He, Pengqin Xu, Zhikang Zhu, Ying Zhang, Chenghao Cai, Yuxiang Zhang, Jiaming Shao, Fang Jin, Qiong Li, Jiahuan You, Hanlei Zhou, Wei Zhang, JintaoWei, Xudong Hong, Zhongtao Zhang, Chunmao Han*, Yuqi Zhang*, Zhen Gu*, Xingang Wang*.

Inflammation-Responsive Hydrogel Accelerates Diabetic Wound Healing Through Immunoregulation and Enhanced Angiogenesis, Advanced Healthcare Materials, 2400150, 2024.

DOI: 10.1002/adhm.202400150

318. Dandan Luo, Jiaqi Xu, Fuyao Liu*, Zhen Gu*.

Advances and Challenges in Cerebral Organoids Research, Advanced NanoBiomed Research, 2300126, 2024.

DOI: 10.1002/anbr.202300126

317. Kexin Su, Lu Shi, Tao Sheng, Xinxin Yan, Lixin Lin, Chaoyang Meng, Shiqi Wu, Yuxuan Chen, Yao Zhang, Chaorong Wang, Zichuan Wang, Junjie Qiu, Jiahui Zhao, Tengfei Xu, Yuan Ping* , Zhen Gu* , Shuai Liu*.

Reformulating Lipid Nanoparticles for Organ-Targeted mRNA Accumulation and Translation, Nature Communications, 15(1): 5659, 2024.

DOI: 10.1038/s41467-024-50093-7

316. Yidan Lyu, Hao Huang, Yuyan Su, Binbin Ying, Wenche Liu, Kairu Dong, Robert S. Langer*, Zhen Gu*, Kewang Nan*.

Macroencapsulated Bacteria for in vivo Sensing & Therapeutics, Matter, in press, 2024.

DOI: 10.1016/j.matt.2024.01.031

315. Xuexiang Zhang, Mohammad Mahdi Hasani-Sadrabadi, Erfan Dashtimighadam, Farahnaz Fahimipour, Bhumika Shokeen, Olga Bezouglaia, Ruxing Fu, Isabelle Hong, Yang Yang, Tara Aghaloo, Benjamin M. Wu, Zhen Gu, Renate Lux, Song Li*.

Dissolvable Microneedle Patch Enables Local Delivery of Immunomodulatory Microparticles Containing Bifunctional Molecules for Periodontal Tissue Regeneration, Med-X, in press, 2024.

DOI: 10.1007/s44258-024-00023-5

314. Xinwei Wei+, Yanfang Wang+, Yun Liu+, Kangfan Ji, Kaihui Li, Jinqiang Wang*, Zhen Gu*.

Biomimetic Design Strategies for Biomedical Applications, Matter, in press, 2024.

DOI: 10.1016/j.matt.2023.12.030

313. Juan Zhang, Xiangqian Wei, Wei Liu, Yanfang Wang, Anna R. Kahkoska, Xianchi Zhou, Huimin Zheng, Wentao Zhang, Tao Sheng, Yang Zhang, Yun Liu, Kangfan Ji, Yichen Xu, Peng Zhang, Jianchang Xu, John. B. Buse, Jinqiang Wang*, Zhen Gu*.

Week-long Norm Glycaemia in Diabetic Mice and Minipigs via A Subcutaneous Dose of A Glucose-responsive Insulin Complex, Nature Biomedical Engineering, in press, 2023.

DOI: 10.1038/s41551-023-01138-7

312. Yuyao Lu+, Geng Yang+，Shenqiang Wang+, Yuqi Zhang+, Yihui Jian, Long He, Ting Yu, Huayu Luo, Depeng Kong, Yun lei Xianyu, Tao Liu, Xiaoping Ouyang, Jicheng Yu, Xinyang Hu, Huayong Yang, Zhen Gu*, Wei Huang, Kaichen Xu*.

Stretchable Graphene Hydrogel Interfaces for Wearable and Implantable Bioelectronics, Nature Electronics, in press, 2023.

DOI: 10.1038/s41928-023-01091-y

311. Shenqiang Wang, Ying Zhang, Yanfang Wang, Yinxian Yang, Sheng Zhao, Tao Sheng, Yuqi Zhang, Zhen Gu* , Jinqiang Wang* , Jicheng Yu*.

An In Situ Dual-anchoring Strategy for Enhanced Immobilization of PD-L1 to Treat Autoimmune Diseases, Nature Communications, 14(1): 6953, 2023.

DOI: 10.1038/s41467-023-42725-1

310. Xiangyang Zhang, Junxia Wang, Ying Zhang, Zhimou Yang, Jie Gao*, Zhen Gu*.

Synthesizing Biomaterials in Living Organisms, Chemical Society Reviews, 52(23): 8126-8164, 2023.

DOI: 10.1039/D2CS00999D

309. Zhen Gu.

Unveiling New Anti-inflammatory Mechanisms of Nanomaterials, National Science Review, 10(12): nwad264, 2023.

DOI: 10.1093/nsr/nwad264

308. Ying Zhang+, Shenqiang Wang+*, Yinxian Yang, Sheng Zhao, Jiahuan You, Junxia Wang, Jingwei Cai, Hao Wang, Jie Wang, Wei Zhang, Jicheng Yu, Chunmao Han, Yuqi Zhang*, Zhen Gu*.

Scarless Wound Healing Programmed by Core-shell Microneedles, Nature Communications, 14(1): 3431, 2023.

DOI: 10.1038/s41467-023-39129-6

307. Mengjia Zheng, Tao Sheng, Jicheng Yu*, Zhen Gu*, Chenjie Xu*.

Microneedles Biomedical Devices, Nature Reviews Bioengineering, in press, 2023.

DOI: 10.1038/s44222-023-00141-6

306. Chaojie Zhu+, Qing Wu+, Tao Sheng+, Jiaqi Shi, Xinyuan Shen, Jicheng Yu, Yang Du, Jie Sun, Tingxizi Liang, Kaixin He, Yuan Ding*, Hongjun Li*, Zhen Gu*, Weilin Wang*.

Rationally Designed Approaches to Augment CAR-T Therapy for Solid Tumor Treatment, Bioactive Materials, 33: 377-395, 2024.

DOI: 10.1016/j.bioactmat.2023.11.002

306. Junjie Yan*, Jinqiang Wang, Xinyu Wang, Donghui Pan, Chen Su, Junxia Wang, Mengzhen Wang, Jianjun Xiong, Yu Chen, Lizhen Wang, Yuping Xu, Chongyang Chen, Min Yang*, Zhen Gu*.

Activating Tumor-selective Liquid Metal Nanomedicine through Galvanic Replacement, Advanced Materials, 2307817, 2023.

DOI: 10.1002/adma.202307817

304. Binbin Ying, Hao Huang, Yuyan Su, Julia G. Howarth, Zhen Gu*, Kewang Nan*.

Theranostic Gastrointestinal Residence Systems, Device, 1(2), 2023.

DOI: 10.1016/j.device.2023.100053

303. Sarun Juengpanich+, Shijie Li+, Taorui Yang+, Tianao Xie, Jiadong Chen, Yukai Shan, Jiyoung Lee, Ziyi Lu, Tianen Chen, Bin Zhang, Jiasheng Cao, Jiahao Hu, Jicheng Yu1, Yanfang Wang, Win Topatana*, Zhen Gu*, Xiujun Cai*, Mingyu Chen*.

Pre-activated Nanoparticles with Persistent Luminescence for Deep Tumor Photodynamic Therapy in Gallbladder Cancer, Nature Communications, 14, 5699, 2023.

DOI: 10.1038/s41467-023-41389-1

302. Mo Chen+, Huangjuan Li+, Jing Zang+, Yueyang Deng, Hongjun Li, Qing Wu, Tianyuan Ci*, Zhen Gu*.

Potentiating Cancer Vaccination by Adjuvant-loaded Cryo-shocked Tumor Cells, Biomaterials, 122319, 2023.

DOI: 10.1016/j.biomaterials.2023.122319

301. Ziqi Gao, Tao Sheng, Wentao Zhang, Jicheng Yu, Zhen Gu*, Yuqi Zhang*.

Microneedle-Mediated Cell Therapy, Advanced Science, 2304124, 2023.

DOI: 10.1002/advs.202304124

300. Yanfang Wang+ , Pengbo Chen+, Wei Liu, Xiangqian Wei, Juan Zhang, Xinwei Wei, Yun Liu, Luxuan Rao, Shiming Zhang, Jicheng Yu, Xiao Ye*, Jinqiang Wang*, Zhen Gu*.

Injectable nanosized formulation for glucose-responsive insulin delivery, Nano Today, 51: 101937, 2023.

DOI: 10.1016/j.nantod.2023.101937

299. Jiahuan You, Changwei Yang, Jinpeng Han, Hao Wang, Wentao Zhang, Ying Zhang, Ziyi Lu, Shiqi Wang, Ruisi Cai, Hongjun Li, Jicheng Yu, Jianqing Gao, Yuqi Zhang*, Zhen Gu*

Ultrarapid-Acting Microneedles for Immediate Delivery of Biotherapeutics, Advanced Materials, 2304582, 2023.

DOI: 10.1002/adma.202304582

298. Yinxian Yang, Yanfang Wang, Yuejun Yao, Shenqiang Wang, Yuqi Zhang, Gianpietro Dotti, Jicheng Yu*, Zhen Gu*.

T Cell-Mimicking Platelet-Drug Conjugates, Matter,6(7), 2340, 2023.

DOI: 10.1016/j.matt.2023.04.026

297. Yun Liu, Yanfang Wang, Yuejun Yao, Juan Zhang, Wei Liu, Kangfan Ji, Xinwei Wei, Yuanwu Wang, Xiangsheng Liu, Shiming Zhang, Jinqiang Wang*, Zhen Gu*.

Glucose-Responsive Charge-Switchable Lipid Nanoparticles for Insulin Delivery, Angewandte Chemie International Edition, 135(20): e202303097, 2023.

DOI: 10.1002/ange.202303097

296. Mingkun Lu, Jiayi Yin, Qi Zhu, Gaole Lin, Minjie Mou, Fuyao Liu, Ziqi Pan, Nanxin You, Xichen Lian, Fengcheng Li, Hongning Zhang, Lingyan Zheng, Wei Zhang, Hanyu Zhang, Zihao Shen, Zhen Gu, Honglin Li*, Feng Zhu*.

Artificial Intelligence in Pharmaceutical Sciences, Engineering,in press, 2023.

DOI: 10.1016/j.eng.2023.01.014

295. Ziyi Lu, Shan Du, Jiaxun Li, Min Zhang, Huali Nie, Xiaojun Zhou, Fulun Li, Xinwei Wei, Jinqiang Wang, Fuyao Liu, Chuanglong He*, Guang Yang*, Zhen Gu*.

Langmuir−Blodgett-mediated formation of antibacterial microneedles for long-term transdermal drug delivery, Advanced Materials, 2303388, 2023.

DOI: 10.1002/adma.202303388

294. Zhou Zhu+, Jian Wang+, Xibo Pei+, Junyu Chen+, Xinwei Wei, Yanhua Liu, Pengcheng Xia, Qianbing Wan*, Zhen Gu*, Yong He*.

Blue-Ringed Octopus Inspired Microneedle Patch for Robust Tissue Surface Adhesion and Active-injection Drug Delivery, Science Advances, 9(25): eadh2213, 2023.

DOI: 10.1126/sciadv.adh2213

293. Wentao Zhang+, Yingxin Chen+, Zhengjie Zhao, Hanqi Zheng, Shenqiang Wang, Ziyan Liao, Sheng Zhao, Wenhui Hou, Xinmin Yu, Fang He, Jicheng Yu, Yuqi Zhang*, Zhen Gu*

Adoptive Treg Therapy with Metabolic Intervention Ameliorated Psoriasis Syndrome by Perforated Microneedles, Science Advances, 9, eadg6007, 2023.

DOI: 10.1126/sciadv.adg6007

292. Yanglong Hou*, Zhen Gu*.

Advanced Biomaterials Research in China, Advanced Healthcare Materials,12(16): 2301336, 2023.

DOI: 10.1002/adhm.202301336

291. Qing Wu+, Hanwei Huang+, Mengchi Sun, Ruizhe Zhang, Junxia Wang, Hanqi Zheng, Chaojie Zhu, Shihua Yang, Xinyuan Shen, Jiaqi Shi, Feng Liu, Wei Wu, Jin Sun, Funan Liu*, Hongjun Li*, Zhen Gu*.

Inhibition of tumor metastasis by liquid nitrogen-shocked tumor cells with oncolytic viruses infection, Advanced Materials, 2212210, 2023.

DOI: 10.1002/adma.202212210

290. En Ren, Yanfang Wang, Tingxizi Liang, Hanqi Zheng, Jiaqi Shi, Zesheng Cheng, Hongjun Li,* Zhen Gu*.

Local Drug Delivery Techniques for Triggering Immunogenic Cell Death, Small Methods, 2300347, 2023.

DOI: 10.1002/smtd.202300347

289. Xiaomeng Dai+,*, Jia Zhang+, Xuanwen Bao+, Yixuan Guo+, Yuzhi Jin, Chenjing Yang, Hangyu Zhang, Lulu Liu, Yang Gao, Chanqi Ye, Wei Wu, Chuan Liu, Chunxia Zhao, Jianpeng Sheng, En Ren, Hongjun Li, Weijia Fang, Baiheng Wu, Jian Ruan*, Zhen Gu*, Dong Chen*, Peng Zhao*.

Induction of Tumor Ferroptosis-Dependent Immunity using an Injectable Attractive Pickering Emulsion Gel, Advanced Materials, 2303542, 2023.

DOI: 10.1002/adma.202303542

288. Changwei Yang+, Tao Sheng+, Wenhui Hou, Juan Zhang, Li Cheng, Hao Wang, Wei Liu, Shiqi Wang, Xinmin Yu, Yuqi Zhang*, Jicheng Yu*, Zhen Gu*.

Glucose-Responsive Microneedle Patch for Closed-Loop Dual-Hormone Delivery in Mice and Pigs, Science Advances, 8(48): eadd3197, 2022.

DOI: 10.1126/sciadv.add3197

287. Tao Sheng, Rui Jin, Changwei Yang, Ke Qiu, Mingyang Wang, Jiaqi Shi, Jingyu Zhang, Yuman Gao, Qing Wu, Xin Zhou, Hao Wang, Juan Zhang, Qin Fang, Neng Pan, Yanan Xue, Yue Wang, Rong Xiong, Fei Gao, Yuqi Zhang, Haojian Lu*, Jicheng Yu*, Zhen Gu*.

Unmanned Aerial Vehicle-Mediated Drug Delivery for First Aid, Advanced Materials, 2208648, 2022.

DOI: 10.1002/adma.202208648

286. Yaxin Shi+, Zhibin Guo+, Qiang Fu+, Xinyuan Shen, Zhongming Zhang, Wenjia Sun, Jinqiang Wang, Junliang Sun, Zizhu Zhang, Tong Liu, Zhen Gu*, Zhibo Liu*.

Localized Nuclear Reaction Breaks Boron Drug Capsules Loaded with Immune Adjuvants for Cancer Immunotherapy, Nature Communications,14, 1884, 2023.

DOI: 10.1038/s41467-023-37253-x

285. Miao Yan, Qing Chen, Tianyi Liu, Xiaofeng Li, Peng Pei, Lei Zhou, Shan Zhou, Runhao Zhang, Kang Liang, Jian Dong, Xunbin Wei, Jinqiang Wang, Osamu Terasaki, Pu Chen, Zhen Gu, Libo Jiang*, Biao Kong*.

Site-Selective Superassembly of Biomimetic Nanorobots Enabling Deep Penetration into Tumor with Stiff Stroma, Nature Communications, 14(1): 4628, 2023.

DOI: 10.1038/s41467-023-40300-2

284. Xiaohong Chen, Shuang Wang, Yuxuan Chen, Huhu Xin, Shuaishuai Zhang, Di Wu, Yanan Xue, Menglei Zha, Hongjun Li, Kai Li, Zhen Gu, Wei Wei*, Yuan Ping*.

Non-invasive Activation of Intratumoural Gene Editing for Improved Adoptive T-cell Therapy in Solid Tumours, Nature Nanotechnology, 18, 933-944, 2023.

DOI: 10.1038/s41565-023-01378-3

283. Kangfan Ji+, Yuejun Yao+, Xinwei Wei, Wei Liu, Juan Zhang, Yun Liu, Yang Zhang, Jinqiang Wang*, Zhen Gu*.

Material Design for Oral Insulin Delivery, Med-X,1, 7, 2023.

DOI: 10.1007/s44258-023-00006-y

282. Xiaojing Chen+, Qianyun Tang+, Jinqiang Wang, Yan Zhou, Fengqin Li, Yuexia Xie, Xingang Wang, Ling Du, Junru Li, Jun Pu, Quanyin Hu, Zhen Gu, Peifeng Liu*.

DNA/DMXAA/metal-organic Framework Activator of Innate Immunity for Boosting Anticancer Immunity, Advanced Materials, 2210440, 2023.

DOI: 10.1002/adma.202210440

281. Wenlong Fu+, Lei Xie+, Jicheng Yu, Yanjun He, Jie Zeng, Jian Liu, Kang Liang, Pu Chen, Lei Jiang, Zhen Gu, Biao Kong*.

In Situ Interfacial Super-Assembly of Nanobiohybrids through Plant for Food-Grade Oral Medicine, ACS Applied Materials & Interfaces, 15, 5, 7282-7293, 2023.

DOI: 10.1021/acsami.2c19791

280. Lizhen He, Jianfu Zhao, Hongjun Li, Bin Xie, Ligeng Xu, Guanning Huang, Ting Liu, Zhen Gu*, Tianfeng Chen*.

Metabolic Reprogramming of Nk Cells by Black Phosphorus Quantum Dots Potentiates Cancer Immunotherapy, Advanced Science, 2202519, 2023.

DOI: 10.1002/advs.202202519

279. Mingyue Wang, Yanfang Wang, Yeteng Mu, Fuxu Yang, Zebin Yang, Yuxuan Liu, Lili Huang, Shi Liu, Xingang Guan*, Zhigang Xie*, Zhen Gu*.

Engineering SIRPα Cellular Membrane-based Nanovesicles for Combination Immunotherapy, Nano Research, 1-9, 2023.

DOI: 10.1007/s12274-023-5397-4

277. Jinpeng Han, Tao Sheng, Yuqi Zhang, Hao Cheng, Jianqing Gao*, Jicheng Yu*, Zhen Gu*.

Bioresponsive Immunotherapeutic Materials, Advanced Materials, 2209778, 2023.

DOI: 10.1002/adma.202209778

276. Yunhong He, Jianwei Wang, Shuping Wang, Kaxi Yu, Jun Zhou, Jinqiang Wang, Guping Tang, Zhen Gu*, Hongzhen Bai*.

Natural Mussel Protein-derived Antitumor Nanomedicine with Tumor-Targeted Bioadhesion and Penetration, Nano Today, 48: 101700, 2023.

DOI: 10.1016/j.nantod.2022.101700

275. Yinxian Yang+, Ruyi Zhou+, Yanfang Wang, Yuqi Zhang, Jicheng Yu*, Zhen Gu*.

Recent Advances in Oral and Transdermal Protein Delivery Systems, Angewandte Chemie International Edition, 62(10): e202214795, 2023.

DOI: 10.1002/anie.202214795

274. Di Wen, Tingxizi Liang, Guojun Chen, Hongjun Li, Zejun Wang, Jinqiang Wang, Ruxing Fu, Xiao Han, Tianyuan Ci, Yuqi Zhang, Peter Abdou, Ruoxing Li, Linlin Bu, Gianpietro Dotti, Zhen Gu*.

Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-associated Macrophages for Cancer Immunotherapy, Advanced Science, 2206001, 2022.

DOI: 10.1002/advs.202206001

273. Ping Wen, Wei Wu, Feifan Wang, Hanqi Zheng, Ziyan Liao, Jiaqi Shi, Chaojie Zhu, Peng Zhao, Hao Cheng*, Hongjun Li*, Zhen Gu.

Cell Delivery Devices for Cancer Immunotherapy, Journal of Controlled Release, 353: 875-888, 2023.

DOI: 10.1016/j.jconrel.2022.11.041

271. Xinyuan Shen+, Chaojie Zhu+, Xutao Liu, Hanqi Zheng, Qing Wu, Jijin Xie, Hao Huang, Ziyan Liao, Jiaqi Shi, Kewang Nan, Xuming Mao, Hongjun Li*, Zhen Gu*.

Engineered bacteria for augmented in situ tumor vaccinations, Biomaterials Science, 11, 1137-1152, 2023.

DOI: 10.1039/D2BM01593E

269. Qian Chen*, Zhisheng Xiao, Chao Wang, Guojun Chen, Yuqi Zhang, Xudong Zhang, Xiao Han, Jinqiang Wang, Xiao Ye, Mark R. Prausnitz, Song Li, Zhen Gu*.

Microneedle Patches Loaded with Nanovesicles for Glucose Transporter-mediated Insulin Delivery, ACS Nano, 16, 11, 18223-18231, 2022.

DOI: 10.1021/acsnano.2c05687

267. Zhanwei Zhou, Ruoxi Yang, Jingwen Dong, Yongxiang Di, Ying Yang, Ying Huang, Xue Yang, Wei Liu, Jinqiang Wang, Peifeng Liu, Zhen Gu*, Minjie Sun*.

Pore forming-mediated intracellular protein delivery for enhanced cancer immunotherapy, Science Advances, 8(46): eabq4659, 2022.

DOI: 10.1126/sciadv.abq4659

266. Jundong Shao, Jing Zhang, Nicolo Antonio Villasis, Xingxing Li, Guojing Chen, Jicheng Yu, Guojun Chen, Yi Gao, Jing Lin, Peng Huang*, Zhen Gu*.

Printable personalized drug delivery patch for the topical therapy of skin diseases, Matter, 6(1): 158-174, 2023.

DOI: 10.1016/j.matt.2022.09.018

265. Tu Hong+, Xinyuan Shen+, Madiha Zahra Syeda, Yang Zhang, Haonan Sheng, Yipeng Zhou, JinMing Xu, Chaojie Zhu, Hongjun Li* , Zhen Gu* Longguang Tang*.

Recent advances of bioresponsive polymeric nanomedicine for cancer therapy, Nano Research, 1-12, 2022.

DOI: 10.1007/s12274-022-5002-2

264. Baoqi Li+, Tianliang Fang+, Yuan Li+, Tianyuan Xue, Zhirang Zhang, Liyan Li, Fanqiang Meng, Jinqiang Wang, Linlin Hou, Xin Liang*, Xudong Zhang*, Zhen Gu*.

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